2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140267
    DBCO-PEG5-acid 2764923-65-9
    DBCO-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG5-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG5-acid
  • HY-130618
    Boc-C1-PEG3-C4-OH 2376724-97-7
    Boc-C1-PEG3-C4-OH is a PROTAC linker, which refers to the Alkyl/ether composition. Boc-C1-PEG3-C4-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    Boc-C1-PEG3-C4-OH
  • HY-140438
    Boc-Aminooxy-PEG4-NH2 2062663-66-3
    Boc-Aminooxy-PEG4-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Aminooxy-PEG4-NH2
  • HY-140398
    m-PEG3-Aminooxy 248275-10-7 98.0%
    m-PEG3-Aminooxy is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG3-Aminooxy
  • HY-141211
    Hydroxy-PEG6-CH2-Boc 297162-47-1
    Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG6-CH2-Boc
  • HY-133372
    DBCO-NHCO-PEG2-maleimide 2698339-31-8
    DBCO-NHCO-PEG2-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG2-maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG2-maleimide
  • HY-133052
    Hydroxy-PEG3-acid 518044-49-0
    Hydroxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG3-acid
  • HY-130162
    Tos-PEG2-O-Propargyl 1119249-30-7 98.47%
    Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458). Tos-PEG2-O-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Tos-PEG2-O-Propargyl
  • HY-W096145
    Chloro-PEG2-Boc 1442085-43-9
    Chloro-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Chloro-PEG2-Boc
  • HY-140696D
    m-PEG-OH (MW 10000) 9004-74-4 99.61%
    m-PEG-OH (MW 10000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.
    m-PEG-OH (MW 10000)
  • HY-120773
    Fmoc-PEG3-C2-NHS ester 1352827-47-4
    Fmoc-PEG3-CH2CH2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG3-C2-NHS ester
  • HY-140307
    Sulfo DBCO-PEG4-Maleimide 2055198-07-5
    Sulfo DBCO-PEG4-Maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Sulfo DBCO-PEG4-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Sulfo DBCO-PEG4-Maleimide
  • HY-W007732B
    Cyclohexane-1,4-diamine 3114-70-3 ≥98.0%
    Cyclohexane-1,4-diamine (1,4-Diaminocyclohexane) is a PROTAC Linker and can be used for PROTAC synthesis, such as TYD-68 (HY-173357).
    Cyclohexane-1,4-diamine
  • HY-W411604
    tert-Butyl hex-5-ynoate 73448-14-3
    tert-Butyl hex-5-ynoate is the linker that can be used for PROTAC synthesis of PROTAC cGAS degrader-1 (HY-172208).
    tert-Butyl hex-5-ynoate
  • HY-140701
    m-PEG-Succinimidyl Succinate (MW 5000)
    m-PEG-Succinimidyl Succinate (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-Succinimidyl Succinate (MW 5000)
  • HY-42618
    Azido-PEG4-CH2-Boc 864681-04-9
    Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-CH2-Boc
  • HY-W019213
    cis-4-Hydroxy-L-proline hydrochloride 441067-49-8
    cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    cis-4-Hydroxy-L-proline hydrochloride
  • HY-126962
    Mal-PEG5-acid 1286755-26-7
    Mal-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Mal-PEG5-acid
  • HY-W591338A
    HO-PEG-CH2COOH (MW 10000) 98.0%
    HO-PEG-CH2COOH (MW 10000) is a PEG polymer with -COOH that can be used as a PROTAC linker to the synthesis of PROTACs.
    HO-PEG-CH2COOH (MW 10000)
  • HY-W096118
    m-PEG2-O-Ph-3-NH2 126415-02-9
    m-PEG2-O-Ph-3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG2-O-Ph-3-NH2
PROTAC Linkers Isoform Comparison

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